SharePoint
If you are using NLB (Network Load Balancing), you may be forced to use Unicast (as I am). This forces you to create another IP address on another NIC to do operations other than NLB, such as domain access, administration, and connecting to a database. You may also have the misfortune of being required to set this NIC to use the same subnet. If you are able to have different subnets, then you need to force all traffic to the database to go out the non-NLB NIC. Do this with Route Add e.g. route -p...