Yesterday, I posted how ClickOnce takes so long to publish because it uploads dotnetfx.exe every time. Well, I found that after you have successfully published you application, you can go to My Project -> Publish -> Prerequisites and uncheck "Create setup program to install prerequisite components". Since the Publish utility doesn't recreate /publish.htm, your application installer will still install dotnetfx.exe on the target computer if needed. And you can have that 10 minutes of your life back.