I've been trying to get NCover to run successfully on Vista Ultimate x64 on and off for the last month. We're still using one of the free versions of NCover available from here, so there is no built-in x64 support. I came across this post today that mentioned using corflags to set the 32BIT flag in both NCover and your testing application (the post is describes using NUnit, but this worked for me with MBUnit as well). Those changes got me past the Profiled process terminated. Profiler connection...