I have switched over to Google Reader (after being a long time FeedDemon user) and am loving the browser-based access anywhere experience. While FeedDemon had great offline reading abilities, if I switched computers I was out of luck. It also doesn't have a sweet Blackberry reading option as does the web-based Google Reader.
Part of this switch also means that instead of laboriously re-posting items I want to share to my blog I can SHIFT + S and easily add them to my shared feed. You can read it in a web view or subscribe to the RSS feed. Be warned: these are things I find interesting. Mileage may vary!