Today I was working on migrating our project from Beta 1 to Beta 2. Sadly it didn't went as smooth as one could expect.
We were getting strange NotSupportedException from mscorlib.dll with message:
Cannot create uninitialized instances of types requiring managed activation.
After spending half of day on debugging it turned out that the reason was some conflict between Remoting and ResourceManager (but probably it happens in serialization). It is thrown if you load any images from resources after configure remoting.
This bug was already reported to Microsoft here and here. The workaround is to configure remoting programmatically rather then using config file.