I wanted to draw everyone's attention to a great new white paper written by my colleague at Neudesic, John Brockmeyer.
BizTalk solutions typically involve a broad swath of technologies, could include Web services, IIS, SQL for data access, FTP, etc.... And, BizTalk itself makes heavy use of SQL. That's a lot of dials and knobs that can be turned to optimize the system.
John knows more about this than perhaps anyone else on the planet, and this white paper is a definitive work that every serious BizTalk developer and administrator should be aware of. You probably won't need everything in here, but there's something in here for everyone.
Awesome work John!
http://msdn2.microsoft.com/en-us/library/bb743398.aspx