Along with HTML5 Boilerplate's rock solid commitment to cross-browser consistency, H5BP brings you delicious documentation, a site optimizing build script, and a custom boilerplate builder. In addition to this, we now support lighttpd, Google App Engine, and NodeJS with optimized server configurations (along with Apache, Nginx, and IIS) and we've reduced the overall size of the published boilerplate by 50%.
You can read more of HTML5Boilerplate at the project website.
A nice way to get started with HTML5Boilerplate can be found at Dan Wahlin’s blog on this post.